Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps.
نویسندگان
چکیده
The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.
منابع مشابه
Genomic Rearrangements CS 373 Fall 2006 Lecture
3. Nadeau JH, Taylor BA “Lengths of chromosomal segments conserved since divergence of man and mouse” Proc. Natl. Acad. Sci, 81(814-818), 1984 4. Wienberg J ‘The evolution of eutherian chromosomes” Curr. Opin. Genet. Dev. 14(657666), 2004 5. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Argawala R, Ainscough R, Alexandersson M, An P “Initial sequencing and comparative a...
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ABC Fax + 41 61 306 12 34 E-mail [email protected] www.karger.com © 2005 S. Karger AG, Basel 0301–0171/05/1083–0139$22.00/0 Accessible online at: www.karger.com/cgr Abstract. For the last 15 years molecular cytogenetic techniques have been extensively used to study primate evolution. Molecular probes were helpful to distinguish mammalian chromosomes and chromosome segments on the basis of their ...
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عنوان ژورنال:
- Science
دوره 309 5734 شماره
صفحات -
تاریخ انتشار 2005